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Chemicals In Great-Grandma’s Life May Promote Disease In You
Chemical exposures during fetal and early postnatal development have been known for quite some time to increase incidences of later life diseases. Examples include fetal exposures to plasticizers such as bisphenol-A leading to immune abnormalities, maternal smoking leading to increased pulmonary disease in adulthood, nutrition defects leading to hypertension, and therapeutic drug exposure leading to vascular defects. In addition to these direct effects of early life exposure on adult onset disease, environmental factors have been shown to directly affect the next 2 generation as well. For example, when an individual with chemical exposure reproduces later in life he/she may be passing on defective genes to their offspring. When that next generation has children, they may also have a chance at expressing those damaged genes as well. Therefore, effects on the first and second generation can be due to direct exposure and so should be considered multigenerational effects. But what about generations after that?
According to a new study by researchers at Washington State University, the chance of a woman getting ovarian disease may be tied to the toxic chemicals her great-grandmother was exposed to.  Michael Skinner and colleagues found certain chemical exposures can “flip a switch”, so to speak, that can promotes ovarian disease for generations down the line. This study could help explain the role of environmental factors in inherited diseases.
Here’s how it works. Picture your great-grandmother. Now let’s say, while pregnant with your future grandparent, she was exposed to some toxic chemical. Pesticides, phthalates — that stuff in plastic — or maybe even jet fuel. It may be that something happens as this toxic substance alters the chemistry of the cell and affects the surrounding DNA in your still-developing grandparent. It isn’t an actual mutation but rather a programming that determines whether a gene is switched on or off.
 “This suggests that environmental compounds and what your ancestors were exposed to — might actually promote a disease in you. And you’re going to pass it on to your children,” Skinner says.
Skinner says the same mechanism could also be contributing to rising cancer rates. The study was published in the journal PLoS One.
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Dr. Iverson's Comment
Remember the Teenage Mutant Ninja Turtles? Toxic waste caused exposed baby turtles to become walking talking ninja warriors idolized by kids everywhere?   Well let’s say this is not so far off the mark!   In this case, toxic waste comes in contact with your ancestors and you—not they—become the mutated turtle.
As you read above these chemicals are altering the DNA turning the genes on or off, but not necessarily mutating them permanently. This, however, is still resulting in ultimately the same effect- disease conditions. Now let’s expand this concept to not only women’s health but also cardiovascular health, respiratory health, endocrine health, bone health… basically any cell that depends on DNA for its function which means all of them! If the DNA of any cell is being affected by chemicals in the environment and those chemicals have the potential to harm not only you but also your children’s children, what are the implications for your grandchildren as they inherit the genes that were damaged from your life but they also accumulate a new burden of chemicals in their life? Starting to see how this could become a real problem in the decades to come? 
Do your best to avoid gross exposure to chemicals. Read chapter 13 in Nature’s Diet to see the sources of these chemicals and read chapter 19 to learn how to detoxify from them. These cleanses should be done at least yearly if not twice yearly to prevent accumulations.
A stitch in time saves nine, an ounce of prevention is worth a pound of cure~
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